High-resolution 1H-FID-MRSI of the human brain at 7T
نویسندگان
چکیده
High quality metabolic mapping of several important brain metabolites (NAA, Cho, Cr, Ins, Glu) was achieved for a 64×64 matrix with a 3.4×3.4×12 mm voxel size in six healthy subjects (Fig.1, Fig.2). Subcutaneous lipids were suppressed by an additional factor of ~12 compared to standard 32×32 matrix (Fig.3). Most notably, the ultra-short TE increased the signal-to-noise ratio of J-coupled resonances, such as the important neurotransmitter, glutamate, by a factor of ~10 compared to commonly used H-MRSI sequences. In addition to the increased SNR and spectral resolution at 7T, this enables reliable quantification of glutamate signals High-resolution 1H-FID-MRSI of the human brain at 7T
منابع مشابه
A new approach to short-TE full-sensitivity MRSI of human brain at 7T
Introduction Magnetic resonance spectroscopy at 7T human scanners provides high signal-to-noise ratio and increased spectral dispersion, which allows the measurement of a large number of metabolites [1]. Spectroscopic imaging enables to obtain metabolic information from multiple voxels simultaneously and to create metabolic maps of the neurochemical profile [2,3]. In this study, a short-TE MRSI...
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